Mesothelioma Information Directory

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giantexplorer.com

Author: Govt

Standard treatment

options:

1. Symptomatic treatment to include drainage of effusions,

   chest tube

   pleurodesis, or thoracoscopic pleurodesis.

2. Palliative surgical resection

   in selected patients.

3. Palliative radiation therapy.
4. Single-agent chemotherapy. Partial responses have been reported with

   doxorubicin, epirubicin, mitomycin, cyclophosphamide, cisplatin, carboplatin,

   and ifosfamide.

5. Combination chemotherapy (under clinical evaluation). Information

   about ongoing clinical trials is available from the NCI

   Cancer.gov Website.

6. Multimodality clinical trials.
7. Intracavitary

   therapy. Intrapleural or intraperitoneal administration

   of

   chemotherapeutic agents (e.g., cisplatin, mitomycin,

   and cytarabine) has been

   reported to produce transient

   reduction in the size of tumor masses and

   temporary control of effusions in small clinical studies. Additional

   studies are needed to define the role of intra-cavitary therapy.

The safety and efficacy of pemetrexed, an antifolate, and

cisplatin in chemotherapy-n aive patients with malignant mesothelioma

who were not eligible for curative

surgery was demonstrated in a large phase III randomized trial. This

trial compared pemetrexed (500 mg/m²) and cisplatin (75

mg/m² on day 1) with cisplatin alone (75 mg/m² on day 1 intravenously every 21 days). A total of 456 patients

were enrolled: 226 patients received pemetrexed plus cisplatin and 222 patients

received cisplatin alone; 8 patients did not receive therapy.
.....[MORE]

Author: U.S. National Library of Medicine

Definition

Benign mesothelioma is a noncancerous tumor

of the pleura (lining of the lung and chest cavity).

Causes, incidence, and risk factors

Nonmalignant mesothelioma is usually a localized

tumor that affects men more frequently than women. The tumor may grow to a large

size and compress the lung, causing the symptoms of shortness of breath.

Symptoms

• chronic

  cough

• shortness of breath

• chest pain

Signs and tests

During a physical examination, the health care provider may notice a clubbed appearance of the fingers.

Tests that may show mesothelioma include the following:

• Chest X-ray

• CT scan of the chest

• Open lung biopsy

Treatment

Surgery is usually necessary for a solitary tumor.

[MORE]

The family of the late paleontologist and evolutionary scientist Stephen Jay Gould sued two Boston hospitals and three doctors Friday, alleging the famed author would still be alive if they had properly diagnosed his cancer four years ago.

Given the advancing age of our surviving World War II veterans, time is short for these particular victims of asbestos-related illnesses.